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Medical Management of Obesity: A Comprehensive Review of FDA-Approved and Investigational Therapies

Sabina (she/her) is the director of the Beauty, Health & Sustainability Lab at the Good Housekeeping Institute, where she has overseen skincare, haircare and makeup testing since 2012

It describes active inflammation as a relative contraindication, on the grounds that nausea and gastrointestinal upset may mimic or trigger a flare

Supporting this hypothesis, a chronic unpredictable mild stress mouse model demonstrated that melatonin effectively restored aquaporin-4 polarization and rectified the compromised glymphatic system observed in this model [215]

In this context, the NAMPT axis could be a potential new target